Johanna Joyce is a Member in the Cancer Biology and Genetics Program at Memorial Sloan Kettering Cancer Center and a Professor in Weill Cornell University Graduate School of Medical Sciences in New York, USA. Dr. Joyce’s group is interested in understanding the microenvironment in which a tumor arises and the critical influence that non-cancerous stromal cells can have on tumor progression and response to therapy. The lab investigates both positive and negative signals provided by the normal tissue stroma to the cancer cells, and how normal cells can be modified by the cancer cells to produce a variety of factors that enhance tumor malignancy. They are also exploring the mechanisms underlying the contribution of the stromal microenvironment to therapeutic resistance, an important area of research that remains largely unexplored. Dr. Joyce aims to ultimately apply this knowledge to the clinic and develop targeted therapies that disrupt these tumor-stromal interactions.
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